Immune Check-Point Inhibitors and Standard Chemoradiotherapy in Definitive Head and Neck Cancer Treatment

被引：13

作者：

De Felice, Francesca ^{[1
]}

Musio, Daniela ^{[1
]}

Tombolini, Vincenzo ^{[1
]}

机构：

[1] Sapienza Univ Rome, Policlin Umberto I, Dept Radiotherapy, I-00161 Rome, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 05期

关键词：

immunotherapy; check-point inhibitors; head neck cancer; chemoradiotherapy; HPV; definitive treatment; outcomes; SQUAMOUS-CELL CARCINOMA; LUNG-CANCER; PHASE-III; NIVOLUMAB; IPILIMUMAB; COMBINATION; OUTCOMES; TRIAL;

D O I：

10.3390/jpm11050393

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

In head and neck cancer management, there is a need for tailored approaches to optimally implement clinical outcomes. Based on the assumption that efficacy and long-term toxicity are not satisfactory for standard concurrent platinum-based chemoradiotherapy, several trials have been designed to test whether induction immunotherapy and/or concomitant immunotherapy and radiotherapy result in improved survival and toxicity outcomes. Here, we present an overview of the most recent concomitant therapeutic strategies for head and neck cancer, focusing on the knowledge available regarding check-point inhibitors. The aim is to present the characteristics of the main check-point inhibitors and to summarize the clinical trials on the combination of immune check-point inhibitors and (chemo)radiotherapy in the definitive HNC setting, in order to provide a useful clinical tool for further research.

引用

页数：10

共 31 条

[1] Real World Outcomes of Ipilimumab and Nivolumab in Patients with Metastatic Melanoma [J].

Asher, Nethanel ;

Ben-Betzalel, Guy ;

Lev-Ari, Shaked ;

Shapira-Frommer, Ronnie ;

Steinberg-Silman, Yael ;

Gochman, Neta ;

Schachter, Jacob ;

Meirson, Tomer ;

Markel, Gal .

CANCERS, 2020, 12 (08) :1-18

[2] The Differences in the Safety and Tolerability of Immune Checkpoint Inhibitors as Treatment for Non-Small Cell Lung Cancer and Melanoma: Network Meta-Analysis and Systematic Review [J].

Chai, Qing-Qing ;

Du, Jiang-Yang ;

Zhu, Jun ;

Wu, Bin .

FRONTIERS IN PHARMACOLOGY, 2019, 10

[3] Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort [J].

Chow, Laura Q. M. ;

Haddad, Robert ;

Gupta, Shilpa ;

Mahipal, Amit ;

Mehra, Ranee ;

Tahara, Makoto ;

Berger, Raanan ;

Eder, Joseph Paul ;

Burtness, Barbara ;

Lee, Se-Hoon ;

Keam, Bhumsuk ;

Kang, Hyunseok ;

Muro, Kei ;

Weiss, Jared ;

Geva, Ravit ;

Lin, Chia-Chi ;

Chung, Hyun Cheol ;

Meister, Amy ;

Dolled-Filhart, Marisa ;

Pathiraja, Kumudu ;

Cheng, Jonathan D. ;

Seiwert, Tanguy Y. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (32) :3838-+

[4] Primary results of the phase III JAVELIN head & neck 100 trial: Avelumab plus chemoradiotherapy (CRT) followed by avelumab maintenance vs CRT in patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) [J].

Cohen, E. E. ;

Ferris, R. L. ;

Psyrri, A. ;

Haddad, R. ;

Tahara, M. ;

Bourhis, J. ;

Harrington, K. J. ;

Chang, P. M-H. ;

Lin, J-C. ;

Razaq, M. ;

Teixeira, M. M. ;

Lovey, J. ;

Chamois, J. ;

Rueda Dominguez, A. ;

Hu, C. ;

Dvorkin, M. ;

De Beukelaer, S. ;

Pavlov, D. ;

Thurm, H. ;

Lee, N. .

ANNALS OF ONCOLOGY, 2020, 31 :S658-S658

[5] Immunotherapy for head and neck cancer: Recent advances and future directions [J].

Cramer, John D. ;

Burtness, Barbara ;

Ferris, Robert L. .

ORAL ONCOLOGY, 2019, 99

[6] Immune check-point in cervical cancer [J].

De Felice, F. ;

Marchetti, C. ;

Palaia, I. ;

Ostuni, R. ;

Muzii, L. ;

Tombolini, V. ;

Panici, P. Benedetti .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2018, 129 :40-43

[7] Late radiation-associated dysphagia in head and neck cancer patients: evidence, research and management [J].

De Felice, F. ;

de Vincentiis, M. ;

Luzzi, V. ;

Magliulo, G. ;

Tombolini, M. ;

Ruoppolo, G. ;

Polimeni, A. .

ORAL ONCOLOGY, 2018, 77 :125-130

[8] Radiotherapy Controversies and Prospective in Head and Neck Cancer: A Literature-Based Critical Review [J].

De Felice, Francesca ;

Polimeni, Antonella ;

Valentini, Valentino ;

Brugnoletti, Orlando ;

Cassoni, Andrea ;

Greco, Antonio ;

de Vincentiis, Marco ;

Tombolini, Vincenzo .

NEOPLASIA, 2018, 20 (03) :227-232

[9] Osteoradionecrosis and intensity modulated radiation therapy: An overview [J].

De Felice, Francesca ;

Musio, Daniela ;

Tombolini, Vincenzo .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2016, 107 :39-43

[10] Treatment improvement and better patient care: which is the most important one in oral cavity cancer? [J].

De Felice, Francesca ;

Musio, Daniela ;

Terenzi, Valentina ;

Valentini, Valentino ;

Cassoni, Andrea ;

Tombolini, Mario ;

De Vincentiis, Marco ;

Tombolini, Vincenzo .

RADIATION ONCOLOGY, 2014, 9 :263

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