Structural Mechanisms for Replicating DNA in Eukaryotes

被引：40

作者：

Attali, Ilan ^{[1
]}

Botchan, Michael R. ^{[2
]}

Berger, James M. ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 | 2021年 / 90卷

关键词：

DNA replication; polymerase; helicase; primase; ATPase; clamp loader; ORC; MCM; PCNA; CELL NUCLEAR ANTIGEN; CRYO-EM STRUCTURE; SISTER-CHROMATID COHESION; LEADING-STRAND SYNTHESIS; MCM2-7; DOUBLE-HEXAMER; IRON-SULFUR CLUSTER; C-TERMINAL DOMAIN; POLYMERASE-EPSILON; CMG HELICASE; ORIGIN RECOGNITION;

D O I：

10.1146/annurev-biochem-090120-125407

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein-nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.

引用

页码：77 / 106

页数：30

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