Predictive factors of para-aortic lymph nodes metastasis in cervical cancer patients: a retrospective analysis based on 723 para-aortic lymphadenectomy cases

被引：49

作者：

Han, Xiaotian ^{[1
,2
]}

Wen, Hao ^{[1
,2
]}

Ju, Xingzhu ^{[1
,2
]}

Chen, Xiaojun ^{[1
,2
]}

Ke, Guihao ^{[1
,2
]}

Zhou, Yuqi ^{[1
,2
]}

Li, Jin ^{[1
,2
]}

Xia, Lingfang ^{[1
,2
]}

Tang, Jia ^{[1
,2
]}

Liang, Shanhui ^{[1
,2
]}

Wu, Xiaohua ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Gynecol Oncol, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 31期

关键词：

cervical cancer; para-aortic lymph node; pelvic lymph node; lymphadenectomy; SCCA; POSITRON-EMISSION-TOMOGRAPHY; SQUAMOUS-CELL CARCINOMA; FOLLOW-UP; STAGE; SURVIVAL; MULTICENTER; STATISTICS; ANTIGEN; IB;

D O I：

10.18632/oncotarget.16025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Para-aortic lymph node (PALN) dissection is optional and controversial in patients with stage IB1-IIA2 cervical cancer. This retrospective study investigated PALN involvement patterns and evaluated preoperative clinical factors. A total of 723 consecutive FIGO stage IB1-IIA2 cervical cancer patients were included in the study. All patients underwent radical hysterectomy/radical trachelectomy, pelvic lymph node dissection, and PALN dissection. PALN metastasis was found in 101 (14.0%) patients, and the positive PALN rates of stage IB1, IB2, IIA1, and IIA2 were 8.4%, 11.1%, 17.2% and 21.7%, respectively. A multivariate model suggested age > 46 years (OR: 1.67, 95% confidence interval (CI): 1.08-2.58), tumor size > 3.5 cm (OR: 1.79, 95% CI: 1.12-2.87), and FIGO stage IIA (vs. IB) (OR: 1.97, 95% CI: 1.25-3.11) all positively correlated with PALN metastasis. When squamous cervical cancer cases were categorically analyzed, a multivariate model indicated age > 46 years (OR: 1.67, 95% CI: 1.00-2.80), FIGO stage IIA (vs. IB) (OR: 1.76, 95% CI: 1.02-3.02), and squamous cell carcinoma antigen (SCCA) > 6.5 ng/ml (OR: 5.20, 95% CI: 3.07-8.81) all positively correlated with PALN metastasis. Age, tumor size, and FIGO stage correlated with PALN metastasis in cervical cancer, while age, FIGO stage, and SCCA level were predictive in squamous cell carcinoma.

引用

页码：51840 / 51847

页数：8

共 30 条

[1]

[Anonymous], NCCN CLIN PRACTICEGU

[2] The Sentinel Node Technique Detects Unexpected Drainage Pathways and Allows Nodal Ultrastaging in Early Cervical Cancer: Insights from the Multicenter Prospective SENTICOL Study [J].