The RAC2-PI3K axis regulates human NK cell maturation and function

被引:10
|
作者
Tabellini, Giovanna [1 ]
Baronio, Manuela [2 ,3 ,4 ]
Patrizi, Ornella [1 ]
Benevenuto, Alessio [2 ,3 ,4 ]
Gazzurelli, Luisa [2 ,3 ,4 ]
Plebani, Alessandro [2 ,3 ,4 ]
Parolini, Silvia [1 ]
Lougaris, Vassilios [2 ,3 ,4 ]
机构
[1] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy
[2] Univ Brescia, Pediat Clin, Piazzale Spedali Civili 1, I-25123 Brescia, Italy
[3] Univ Brescia, Inst Mol Med A Nocivelli, Dept Clin & Expt Sci, Piazzale Spedali Civili 1, I-25123 Brescia, Italy
[4] ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, I-25123 Brescia, Italy
关键词
RAC2; PI3K; NK cells; Cytotoxicity; p110d;
D O I
10.1016/j.clim.2019.108257
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Glycosylation regulates NK cell-mediated effector function through PI3K pathway
    Benson, Veronika
    Grobarova, Valika
    Richter, Jan
    Fiserova, Anna
    INTERNATIONAL IMMUNOLOGY, 2010, 22 (03) : 167 - 177
  • [2] Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function
    Yu, Minghang
    Su, Ziyang
    Huang, Xuefeng
    Zhou, Yujie
    Zhang, Xulong
    Wang, Bingbing
    Wang, Zihan
    Liu, Yi
    Xing, Nianzeng
    Xia, Miaoran
    Wang, Xi
    JOURNAL OF LEUKOCYTE BIOLOGY, 2021, 110 (06) : 1033 - 1045
  • [3] GATA2-TGF-b1 axis regulates human NK cell development
    Wang, Dandan
    Myers, Kasiani C.
    Bresnick, Emery H.
    Verbsky, James
    Thakar, Monica
    Malarkannan, Subramaniam
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [4] NFKB1 regulates human NK cell maturation and effector functions
    Lougaris, Vassilios
    Patrizi, Ornella
    Baronio, Manuela
    Tabellini, Giovanna
    Tampella, Giacomo
    Damiati, Eufemia
    Frede, Natalie
    van der Meer, Jos W. M.
    Fliegauf, Manfred
    Grimbacher, Bodo
    Parolini, Silvia
    Plebani, Alessandro
    CLINICAL IMMUNOLOGY, 2017, 175 : 99 - 108
  • [5] PI3Kα and PI3Kβ Have Distinct Roles in Rodent and Human β-Cell Function
    Kolic, Jelena
    Plummer, Gregory
    Leung, Eric
    Fox, Jocelyn E. Manning
    Macdonald, Patrick E.
    DIABETES, 2011, 60 : A97 - A97
  • [6] GATA2-TAL1 Axis Is Essential for Human NK Cell Development and Function
    Wang, Dandan
    Zhang, Fangfei
    Veltri, Anthony
    Pulikkan, John Anto
    Rao, Sridhar
    Malarkannan, Subramaniam
    BLOOD, 2023, 142
  • [7] Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes
    Kerr, Bethany A.
    Otani, Tomohiro
    Koyama, Eiki
    Freeman, Theresa A.
    Enomoto-Iwamoto, Motomi
    EXPERIMENTAL CELL RESEARCH, 2008, 314 (06) : 1301 - 1312
  • [8] Interaction of suppressor of cytokine signaling 2 with phosphorylated Pyk2 regulates human NK cell function
    Jung, Haiyoung
    Lee, Suk Hyung
    Park, Young-Jun
    Yoon, Suk Ran
    Choi, Inpyo
    JOURNAL OF IMMUNOLOGY, 2011, 186
  • [9] PI3Kδ is required for NK Cell innate immunity to tumours
    Saudemont, A.
    Okkenhaug, K.
    Colucci, F.
    IMMUNOLOGY, 2007, 120 : 34 - 34
  • [10] SHP-2 Expression Negatively Regulates NK Cell Function
    Purdy, Amanda K.
    Campbell, Kerry S.
    JOURNAL OF IMMUNOLOGY, 2009, 183 (11): : 7234 - 7243