Multimodal imaging of language reorganization in patients with left temporal lobe epilepsy

被引：23

作者：

Chang, Yu-Hsuan A. ^{[1
,2
]}

Kemmotsu, Nobuko ^{[2
]}

Leyden, Kelly M. ^{[2
]}

Kucukboyaci, N. Erkut ^{[3
]}

Iragui, Vicente J. ^{[4
]}

Tecoma, Evelyn S. ^{[4
]}

Kansal, Leena ^{[4
]}

Norman, Marc A. ^{[2
]}

Compton, Rachelle ^{[4
]}

Ehrlich, Tobin J. ^{[5
]}

Uttarwar, Vedang S. ^{[1
,2
]}

Reyes, Anny ^{[1
,2
,3
]}

Paul, Brianna M. ^{[6
,7
]}

McDonald, Carrie R. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Diego, Ctr Multimodal Imaging & Genet, 9452 Med Ctr Dr, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA

[3] SDSU UC San Diego Joint Doctoral Program Clin Psy, San Diego, CA USA

[4] Univ Calif San Diego, Dept Neurosci, 9500 Gilman Dr, La Jolla, CA 92093 USA

[5] Palo Alto Univ, 1971 Arastradero Dr, Palo Alto, CA 94304 USA

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[7] UCSF Comprehens Epilepsy Ctr, San Francisco, CA USA

来源：

BRAIN AND LANGUAGE | 2017年 / 170卷

基金：

美国国家卫生研究院;

关键词：

Temporal lobe epilepsy; Cortical thickness; DTI; Functional MRI; Language; FUNCTIONAL MRI; CORTICAL THICKNESS; SURFACE RECONSTRUCTION; ARCUATE FASCICULUS; COMBINED FMRI; SMALL-WORLD; LATERALIZATION; DOMINANCE; TRACTOGRAPHY; ACTIVATION;

D O I：

10.1016/j.bandl.2017.03.012

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE). Fourteen patients with LTLE and 26 controls underwent structural MRI, functional MRI, diffusion tensor imaging, and neuropsychological language tasks. Laterality indices were calculated for each imaging modality and a principal component (PC) was derived from language measures. Correlations were performed among imaging measures, as well as to the language PC. In controls, better language performance was associated with stronger left- lateralized temporo-parietal and temporo-occipital activations. In LTLE, better language performance was associated with stronger right-lateralized inferior frontal, temporo-parietal, and temporo-occipital activations. These right-lateralized activations in LTLE were associated with right-lateralized arcuate fasciculus fractional anisotropy. These data suggest that interhemispheric language reorganization in LTLE is associated with alterations to perisylvian white matter. These concurrent structural and functional shifts from left to right may help to mitigate language impairment in LTLE. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：82 / 92

页数：11

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