Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

被引：47

作者：

Grecco, Simone S. ^{[1
]}

Reimao, Juliana Q. ^{[2
]}

Tempone, Andre G. ^{[2
]}

Sartorelli, Patricia ^{[1
]}

Romoff, Paulete ^{[3
,4
]}

Ferreira, Marcelo J. P. ^{[3
,4
]}

Favero, Oriana A. ^{[3
,4
]}

Lago, Joao H. G. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP, Brazil

[2] Inst Adolfo Lutz Registro, Div Biol Med, Serv Parasitol, Lab Toxinol Aplicada, BR-01246000 Sao Paulo, Brazil

[3] Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo, Brazil

[4] Univ Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, BR-01302907 Sao Paulo, Brazil

来源：

PARASITOLOGY RESEARCH | 2010年 / 106卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

TRYPANOSOMA-CRUZI; IN-VITRO; LEISHMANIASIS; FLAVONOIDS; DRUGS;

D O I：

10.1007/s00436-010-1771-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.

引用

页码：1245 / 1248

页数：4

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