Controllable preparation and performance of bio-based poly(lactic acid-iminodiacetic acid) as sustained-release Pb2+ chelating agent

被引：10

作者：

Lin, Jian-Yun ^{[1
]}

Cao, Xi-Ying ^{[1
]}

Xiao, Ying ^{[1
]}

Wang, Jin-Xin ^{[1
]}

Luo, Shi-He ^{[1
,2
]}

Yang, Li-Ting ^{[1
]}

Fang, Yong-Gan ^{[1
]}

Wang, Zhao-Yang ^{[1
,2
]}

机构：

[1] South China Normal Univ, Sch Chem, Key Lab Theoret Chem Environm, Minist Educ,Guangzhou Key Lab Analyt Chem Biomed, Guangzhou 510006, Peoples R China

[2] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, 381 Wushan Rd, Guangzhou 510640, Peoples R China

来源：

ISCIENCE | 2021年 / 24卷 / 06期

基金：

中国国家自然科学基金;

关键词：

DIRECT MELT POLYCONDENSATION; BIOAVAILABILITY; POLYMERIZATION; NANOCOMPOSITE; EXTRACTION; BARRIERS; IONS;

D O I：

10.1016/j.isci.2021.102518

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The bio-based lactic acid (LA) and the common metal ion chelating agent iminodiacetic acid (IDA) are used to design and prepare a polymeric sustained-release Pb2+ chelating agent by a brief one-step reaction. After the analysis on theoretical calculation for this reaction, poly(lactic acid-iminodiacetic acid) [P(LA-co-IDA)] with different monomer molar feed ratios is synthesized via direct melt polycondensation. P(LA-co-IDA) mainly has star-shaped structure, and some of them have two-core or three-core structure. Thus, a possible mechanism of the polymerization is proposed. The degradation rate of P(LA-co-IDA)s can reach 70% in 4 weeks. The change of IDA release rate is consistent with the trend of the degradation rate, and the good Pb2+ chelating performance is confirmed. P(LA-co-IDA) is expected to be developed as a lead poisoning treatment drug or Pb2+ adsorbent in the environment with long-lasting effect, and this research provides a new strategy for the development of such drugs.

引用

页数：18

共 65 条

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