Getting under the Skin: The Immunopathogenesis of Streptococcus pyogenes Deep Tissue Infections

被引：107
作者：
Johansson, Linda [1 ]
Thulin, Pontus [1 ,2 ]
Low, Donald E. [3 ,4 ]
Norrby-Teglund, Anna [1 ]
机构：
[1] Karolinska Inst, Ctr Infect Med, Karolinska Univ Hosp Huddinge, S-141866 Stockholm, Sweden
[2] Univ Hosp Orebro, Dept Urol, Orebro, Sweden
[3] Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada
[4] Ontario Agcy Hlth Protect & Promot, Toronto, ON, Canada
来源：
CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 01期
基金：
瑞典研究理事会;
关键词：
GROUP-A STREPTOCOCCI; TOXIC-SHOCK-SYNDROME; POLYSPECIFIC IMMUNOGLOBULIN; SUPERANTIGEN INVOLVEMENT; ANTIMICROBIAL PEPTIDES; NECROTIZING FASCIITIS; M-PROTEIN; T-CELLS; IN-VIVO; VIRULENCE;
D O I：
10.1086/653116
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Streptococcus pyogenes can cause a variety of diseases in immunocompetent individuals, from pharyngotonsillitis to life-threatening invasive diseases, such as streptococcal toxic shock syndrome, and rapidly progressing deep-tissue infections, such as necrotizing fasciitis. Necrotizing fasciitis is often seen in combination with streptococcal toxic shock syndrome, which further increases morbidity and mortality. We review here the host-pathogen interactions in the tissue milieu and discuss the use of intravenous immunoglobulin as potential adjunctive therapy in these life-threatening infections.
引用
收藏
页码：58 / 65
页数：8
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