High expression of NDRG3 correlates with poor prognosis in gastric cancer patients

Introduction: N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague. Material and methods: Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection. Results: NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival. Discussion: thus, NDRG3 may be a novel predictor of GC prognosis.