KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients

被引：16

作者：

Rizzo, Roberta ^{[1
]}

Bortolotti, Dania ^{[1
]}

Fainardi, Enrico ^{[2
]}

Gentili, Valentina ^{[1
]}

Bolzani, Silvia ^{[1
]}

Baldi, Eleonora ^{[3
]}

Casetta, Ilaria ^{[4
]}

Granieri, Enrico ^{[4
]}

Rotola, Antonella ^{[1
]}

Furlan, Roberto ^{[5
]}

Di Luca, Dario ^{[1
]}

机构：

[1] Univ Ferrara, Sect Microbiol & Med Genet, Dept Med Sci, Via Luigi Borsari 46, I-44121 Ferrara, Italy

[2] Azienda Osped Univ, Dept Neurosci & Rehabil, Neuroradiol Unit, Ferrara, Italy

[3] Azienda Osped Univ, Dept Neurosci & Rehabil, Neurol Unit, Ferrara, Italy

[4] Univ Ferrara, Dept Biomed & Specialist Surg Sci, Neurol Sect, I-44100 Ferrara, Italy

[5] Ist Sci San Raffaele, Div Neurosci, INSPE, I-20132 Milan, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 294卷

关键词：

NK cells; Inhibitory receptor; Host/pathogens interactions; Herpesvirus; Th17; VIRUS-INFECTION; KILLER; RECEPTOR; MOLECULES; SUBSETS; CLONES;

D O I：

10.1016/j.jneuroim.2016.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously demonstrated that multiple sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2(+) NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2(-) NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2(+) NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

共 8 条

[1] Evaluation of the implication of KIR2DL2 receptor in multiple sclerosis and herpesvirus susceptibility
Ben Fredj, Nadia
Rizzo, Roberta
Bortolotti, Daria
Nefzi, Faten
Chebel, Saber
Rotola, Antonella
Frih-Ayed, Mahbouba
Di Luca, Dario
Aouni, Mahjoub
JOURNAL OF NEUROIMMUNOLOGY, 2014, 271 (1-2) : 30 - 35
[2] Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression
Rizzo, Roberta
Gentili, Valentina
Casetta, Ilaria
Caselli, Elisabetta
De Gennaro, Riccardo
Granieri, Enrico
Cassai, Enzo
Di Luca, Dario
Rotola, Antonella
JOURNAL OF NEUROIMMUNOLOGY, 2012, 251 (1-2) : 55 - 64
[3] Herpesvirus Infections in KIR2DL2-Positive Multiple Sclerosis Patients: Mechanisms Triggering Autoimmunity
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Gentili, Valentina
Bortoluzzi, Alessandra
Govoni, Marcello
Schiuma, Giovanna
Beltrami, Silvia
Rizzo, Sabrina
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MICROORGANISMS, 2022, 10 (03)
[4] IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells
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[5] Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients
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[6] Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response
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[7] Effect of Estrogen on Th1, Th2 and Th17 Cytokines Production by Proteolipid Protein and PHA Activated Peripheral Blood Mononuclear Cells Isolated from Multiple Sclerosis Patients
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