The GGA proteins: key players in protein sorting at the trans-Golgi network

被引：68

作者：

Ghosh, P ^{[1
]}

Kornfeld, S ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2004年 / 83卷 / 06期

关键词：

D O I：

10.1078/0171-9335-00374

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The GGA ((G) under bar olgi-localized, (gamma) under bar -ear containing, (A) under bar DP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.

引用

页码：257 / 262

页数：6

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