Selective brain cooling: a multiple regulatory mechanism

The mechanism of selective brain cooling (SBC) allows the brain to remain cooler than the rest of the body. This paper aims to provide new ideas to better understand SBC, emphasizing how it works, how it is controlled and what its role is. There are two distinct types of SBC in homeotherms: (1) using precooling of arterial blood destined for the brain, with cool venous blood returning from the nose and head skin, (2) using venous blood to cool the brain directly. There is a common mechanism of control of SBC intensity. Reduced sympathetic activity leads to simultaneous dilation of the angular oculi veins, supplying the intracranial heat exchangers, and constriction of the facial veins, supplying the heart. Therefore, SBC is enhanced during heat exposure, endurance exercise, relaxed wakefulness and NREM sleep, and vanishes in the cold and during emotional distress. SBC is a multifunctional effector mechanism: it protects the brain from heat damage; it intensifies in dehydrated mammals, thereby saving water; it helps exercising animals delay exhaustion; it might thermally modulate alertness; it is used in diving animals to drop cerebral temperature much below its normal level, expanding diving capacity and protecting the brain from asphyxic damage. Altogether, SBC integrates both thermal and non-thermal regulatory functions. (C) 2004 Elsevier Ltd. All rights reserved.