Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells

被引：24
作者：
Lee, Sung Ryul
Kwak, Jong Hwan
Kim, Hyoung Ja
Pyo, Suhkneung [1 ]
机构：
[1] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea
[2] Korea Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 07期
关键词：
kobophenol A; SH-SY5Y; neuroprotection;
D O I：
10.1016/j.bmcl.2007.01.078
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study examined the neuroprotective effects of kobophenol A (kob A), oligomeric stillbene, and a resveratrol tetramer. Neuronal death induced by the withdrawal of tropic support was ameliorated by kob A. The protective effect of kob A against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1879 / 1882
页数：4
相关论文
共 23 条
[1]   Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson's disease [J].
Andersen, JK .
NEUROTOXICITY RESEARCH, 2003, 5 (05) :307-313
[2]  
Carreras Maria C., 2004, Molecular Aspects of Medicine, V25, P125, DOI 10.1016/j.mam.2004.02.014
[3]   Characterization of chronic low-level proteasome inhibition on neural homeostasis [J].
Ding, QX ;
Dimayuga, E ;
Martin, S ;
Bruce-Keller, AJ ;
Nukala, V ;
Cuervo, AM ;
Keller, JN .
JOURNAL OF NEUROCHEMISTRY, 2003, 86 (02) :489-497
[4]   Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson's disease [J].
Eve, DJ ;
Nisbet, AP ;
Kingsbury, AE ;
Kingsbury, AE ;
Hewson, EL ;
Daniel, SE ;
Lees, AJ ;
Marsden, CD ;
Foster, OJF .
MOLECULAR BRAIN RESEARCH, 1998, 63 (01) :62-71
[5]   p38 MAP kinase mediates Bax translocation in nitric oxide-induced apoptosis in neurons [J].
Ghatan, S ;
Larner, S ;
Kinoshita, Y ;
Hetman, M ;
Patel, L ;
Xia, ZG ;
Youle, RJ ;
Morrison, RS .
JOURNAL OF CELL BIOLOGY, 2000, 150 (02) :335-347
[6]  
Guarneri P, 2000, J NEUROSCI RES, V60, P656, DOI 10.1002/(SICI)1097-4547(20000601)60:5<656::AID-JNR11>3.0.CO
[7]  
2-6
[8]   Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neurons [J].
Harada, J ;
Sugimoto, M .
BRAIN RESEARCH, 1999, 842 (02) :311-323
[9]  
Jung P.S., 1990, HYANGYAK DAESAGEON, P669
[10]   Neurotoxic nitric oxide rapidly depolarizes and permeabilizes mitochondria by dynamically opening the mitochondrial transition pore [J].
Kindler, DD ;
Thiffault, C ;
Solenski, NJ ;
Dennis, J ;
Kostecki, V ;
Jenkins, R ;
Keeney, PM ;
Bennett, JP .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (04) :559-573
123