Neuroimaging Findings in a Patient with Anti-IgLON5 Disease: Cerebrospinal Fluid Dynamics Abnormalities

被引：6

作者：

Urso, Daniele ^{[1
,2
]}

De Blasi, Roberto ^{[3
]}

Anastasia, Antonio ^{[3
]}

Gnoni, Valentina ^{[1
,2
]}

Rizzo, Valentina ^{[3
]}

Nigro, Salvatore ^{[1
]}

Tafuri, Benedetta ^{[1
,4
]}

Iacolucci, Carlo Maria ^{[1
]}

Zecca, Chiara ^{[1
]}

Dell'Abate, Maria Teresa ^{[1
]}

Andreetta, Francesca ^{[5
]}

Logroscino, Giancarlo ^{[1
,4
]}

机构：

[1] Univ Bari Aldo Moro, Pia Fdn Cardinale G Panico, Ctr Neurodegenerat Dis & Aging Brain, Dept Clin Res Neurol, I-73039 Tricase, Italy

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neurosci, De Crespigny Pk, London SE5 8AF, England

[3] Pia Fdn Culto & Relig Card G Panico, Dept Diagnost Imaging, I-73039 Tricase, Italy

[4] Univ Bari Aldo Moro, Dept Basic Med Neurosci & Sense Organs, I-70124 Bari, Italy

[5] Fdn IRCCS Ist Neurol Carlo Besta, Neurol Neuroimmunol & Neuromuscular Dis Unit 4, I-20133 Milan, Italy

来源：

DIAGNOSTICS | 2022年 / 12卷 / 04期

关键词：

anti-IgLON5; disease; neuroimaging; PSP; MRI; nuclear medicine; cerebrospinal fluid dynamics;

D O I：

10.3390/diagnostics12040849

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-IgLON5 disease is a recently described autoimmune neurodegenerative disorder characterized by insidious onset, slow progression and a variety of neurological features. Neuroimaging in most patients with anti-IgLON5 disease is normal or shows nonspecific findings. Here, we report a case of anti-IgLON5 disease presenting with parkinsonism, falls, sleep problems with severe nocturnal dyspnea attacks, dysphagia, and dysautonomia. Imaging findings were initially suggestive of progressive supranuclear palsy. An altered cerebrospinal fluid dynamic was found on an MRI as well as high-convexity hyperperfusion on a brain SPECT. Further case descriptions with neuroimaging are required to characterize cerebral and cerebrospinal fluid dynamics abnormalities in this rare condition.

引用

页数：4

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