Biodegradable thermogel as culture matrix of bone marrow mesenchymal stem cells for potential cartilage tissue engineering

被引：25

作者：

Zhang, Yan-bo ^{[1
,2
]}

Ding, Jian-xun ^{[2
,3
]}

Xu, Wei-guo ^{[2
]}

Wu, Jie ^{[2
]}

Chang, Fei ^{[1
]}

Zhuang, Xiu-li ^{[2
,3
]}

Chen, Xue-si ^{[2
,3
]}

Wang, Jin-cheng ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Orthoped, Changchun 130041, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[3] Changchun SinoBiomat Co Ltd, Changchun 130103, Peoples R China

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2014年 / 32卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Bone marrow mesenchymal stem cell; Cartilage defect repair; Scaffold; Thermogel; PHASE-TRANSITION; IN-VITRO; MICELLES; DELIVERY; DIFFERENTIATION; SCAFFOLDS; COPOLYMER; HYDROGELS; REPAIR;

D O I：

10.1007/s10118-014-1551-5

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations (> 15 wt%). The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEG-PLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.

引用

页码：1590 / 1601

页数：12

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