RADIATION DOSE-VOLUME EFFECTS IN THE LUNG

被引：798
作者：
Marks, Lawrence B. [1 ]
Bentzen, Soren M. [2 ]
Deasy, Joseph O. [3 ]
Kong, Feng-Ming [4 ]
Bradley, Jeffrey D. [3 ]
Vogelius, Ivan S. [2 ]
El Naqa, Issam [3 ]
Hubbs, Jessica L. [1 ]
Lebesque, Joos V. [5 ]
Timmerman, Robert D. [6 ]
Martel, Mary K. [7 ]
Jackson, Andrew [8 ]
机构：
[1] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC 27514 USA
[2] Univ Wisconsin, Sch Med, Dept Human Oncol, Madison, WI USA
[3] Washington Univ, Sch Med, Dept Radiat Oncol, Alvin J Siteman Canc Ctr, St Louis, MO USA
[4] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
[5] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands
[6] Univ Texas SW, Dept Radiat Oncol, Dallas, TX USA
[7] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA
[8] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 76卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Lung injury; Radiation; QUANTEC; Pneumonitis; INTENSITY-MODULATED RADIOTHERAPY; TREATMENT-RELATED PNEUMONITIS; THERAPY-ONCOLOGY-GROUP; CANCER-PATIENTS; PULMONARY TOXICITY; HISTOGRAM ANALYSIS; CONCURRENT CHEMOTHERAPY; INTERSTITIAL PNEUMONITIS; CONFORMAL RADIOTHERAPY; REGIONAL DIFFERENCES;
D O I：
10.1016/j.ijrobp.2009.06.091
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects. (C) 2010 Elsevier Inc.
引用
收藏
页码：S70 / S76
页数：7
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