Research advances on circulating long noncoding RNAs as biomarkers of cardiovascular diseases

被引：43
作者：
Cao, Mingyi [1 ]
Luo, Huishan [1 ]
Li, Danning [1 ]
Wang, Shengjie [1 ]
Xuan, Lina [1 ]
Sun, Lihua [1 ]
机构：
[1] Harbin Med Univ, State Prov Key Labs Biomed Pharmaceut China Key L, Coll Pharm, Dept Pharmacol, Harbin, Heilongjiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2022年 / 353卷
基金：
中国国家自然科学基金;
关键词：
LncRNA; Biomarker; Cardiovascular diseases; ISCHEMIA-REPERFUSION INJURY; CARDIOMYOCYTE APOPTOSIS; MYOCARDIAL-INFARCTION; TRANSCRIPTION FACTOR; LNCRNA GAS5; RISK; LIPCAR; AXIS; H19; PROLIFERATION;
D O I：
10.1016/j.ijcard.2022.01.070
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular diseases (CVD) such as myocardial ischemia, myocardial infarction, heart failure, atherosclerosis, hypertension, arrhythmia, and their complications diseases are associated with increased morbidity and mortality, it is necessary to develop new diagnostic markers for CVD. LncRNAs have become a new class of biomarkers in CVD with good development prospects. Numerous studies have confirmed lncRNAs feasibility as diagnostic, prognostic and predictive tools for different types of CVD. In this review, we summarized the available knowledge regarding the clinical application value and pathophysiological mechanism of circulating lncRNA as potential biomarkers of cardiovascular disease. We reviewed the scope of application and changes of circulating lncRNAs such as ZFAS1, CDR1AS, CHAST, UCA1, HOTAIR, MIAT, NEAT1, LIPCAR, H19, NRF, NRON, MHRT, PVT1, Heat2, CASC7, GAS5, MALAT1, APPAT, HIF1A-AS1, KCNQ1OT1, NEXN in different kinds of CVD and discussed their clinical application potential as biomarker, which can help us better understand the mechanism of CVD.
引用
收藏
页码：109 / 117
页数：9
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