AMD3100/Plerixafor overcomes immune inhibition by the CXCL12-KRT19 coating on pancreatic and colorectal cancer cells

被引：18

作者：

Fearon, Douglas T. ^{[1
,2
]}

Janowitz, Tobias ^{[1
,3
]}

机构：

[1] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

[2] Weill Cornell Med, New York, NY 10021 USA

[3] Northwell Hlth, Canc Inst, New Hyde Pk, NY USA

来源：

BRITISH JOURNAL OF CANCER | 2021年 / 125卷 / 02期

关键词：

IMMUNOTHERAPY;

D O I：

10.1038/s41416-021-01315-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A recent Phase 1 clinical study of the immunological effects of inhibiting the chemokine receptor, CXCR4, in patients with pancreatic ductal adenocarcinoma or colorectal cancer suggests that stimulation of CXCR4 on immune cells suppresses the intratumoural immune reaction. Here, we discuss how CXCR4 mediates this response, and how cancer cells elicit it.

引用

页码：149 / 151

页数：3

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