Neonatal asphyxia and hyperthermia and cognitive deficits in adult rats: Role of iron

被引：6

作者：

Rogalska, Justyna ^{[1
]}

Caputa, Michal ^{[1
]}

Piatkowska, Katarzyna ^{[1
]}

Nowakowska, Anna ^{[1
]}

机构：

[1] Nicholas Copernicus Univ, Dept Anim Physiol, Inst Gen & Mol Biol, PL-87100 Torun, Poland

来源：

JOURNAL OF THERMAL BIOLOGY | 2009年 / 34卷 / 08期

关键词：

Rats; Neonatal asphyxia; Hyperthermia; Iron; Deferoxamine; Behaviour; Memory disturbances; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; FREE-RADICAL PRODUCTION; OXIDATIVE STRESS; BODY-TEMPERATURE; BRAIN-INJURY; POSTISCHEMIC HYPOTHERMIA; ANOXIA; DEFEROXAMINE; BEHAVIOR; OUTCOMES;

D O I：

10.1016/j.jtherbio.2009.08.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We compared effects of a critical neonatal anoxia, applied in Wistar rats at body temperatures of 33, 37 and 39 degrees C, on memory performance in adulthood. Because hyperthermic-anoxic neonates suffer from hyperferremia an additional group of rats, exposed to anoxia at 39 degrees C, was injected with deferoxamine, a chelator of iron. At the age of 4 and 12 months all rats were examined in hole board, typical maze and Morris maze. The memory was disturbed by neonatal anoxia at 39 degrees C. The disturbances were prevented by both the naturally reduced body temperature and by deferoxamine. In conclusion, neonatal hyperthermia induces iron-mediated, extremely delayed postanoxic cognitive disturbances in adulthood. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：391 / 400

页数：10

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