Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals

被引：3
|
作者：
Hemachudha, P. [1 ,2 ]
Petcharat, S. [1 ]
Ampoot, W. [1 ]
Ponpinit, T. [1 ]
Paitoonpong, L. [3 ]
Hemachudha, T. [1 ,2 ]
机构：
[1] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med,World Hlth Organ Collaborating Ctr Res &, Thai Red Cross Emerging Infect Dis Hlth Sci Ctr, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Dept Med, Div Neurol, Bangkok, Thailand
[3] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med,Div Infect Dis,Dept Med, Thai Red Cross Emerging Infect Dis Clin Ctr, Bangkok 10330, Thailand
来源：
NEW MICROBES AND NEW INFECTIONS | 2022年 / 45卷
关键词：
next generation sequencing; SARS-CoV-2; COVID-19; genetic variations;
D O I：
10.1016/j.nmni.2022.100950
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding and may also affect binding affinity for favipiravir. (c) 2022 The Author(s). Published by Elsevier Ltd.
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页数：3
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