Escaping the immune system by DNA repair and recombination in African trypanosomes

被引：21
作者：
Sima, Nuria [1 ]
McLaughlin, Emilia Jane [1 ]
Hutchinson, Sebastian [2 ,3 ]
Glover, Lucy [1 ]
机构：
[1] Inst Pasteur, Dept Parasites & Insect Vectors, Trypanosome Mol Biol, 25-28 Rue Docteur Roux, F-75015 Paris, France
[2] Inst Pasteur, Dept Parasites & Insect Vectors, Trypanosome Cell Biol, 25-28 Rue Docteur Roux, F-75015 Paris, France
[3] Inst Pasteur, Dept Parasites & Insect Vectors, INSERM U1201, 25-28 Rue Docteur Roux, F-75015 Paris, France
来源：
OPEN BIOLOGY | 2019年 / 9卷 / 11期
基金：
欧盟地平线“2020”;
关键词：
VSG switching; DNA damage; homologous; recombination; VARIANT SURFACE GLYCOPROTEIN; VSG EXPRESSION SITE; RNA-POLYMERASE-I; BRC REPEAT NUMBER; ANTIGENIC VARIATION; HOMOLOGOUS RECOMBINATION; GENE CONVERSION; TELOMERE LENGTH; BRUCEI; MECHANISMS;
D O I：
10.1098/rsob.190182
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
African trypanosomes escape the mammalian immune response by antigenic variation-the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one. VSG transcription is monoallelic, with only one VSG being expressed at a time from a specialized locus, known as an expression site. VSG switching is a predominantly recombination-driven process that allows VSG sequences to be recombined into the active expression site either replacing the currently active VSG or generating a 'new' VSG by segmental gene conversion. In this review, we describe what is known about the factors that influence this process, focusing specifically on DNA repair and recombination.
引用
收藏
页数：9
相关论文
共 113 条
  • [1] VSG switching in Trypanosoma brucei:: antigenic variation analysed using RNAi in the absence of immune selection
    Aitcheson, N
    Talbot, S
    Shapiro, J
    Hughes, K
    Adkin, C
    Butt, T
    Sheader, K
    Rudenko, G
    [J]. MOLECULAR MICROBIOLOGY, 2005, 57 (06) : 1608 - 1622
  • [2] A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
    Alsford, Sam
    Kawahara, Taemi
    Isamah, Cyril
    Horn, David
    [J]. MOLECULAR MICROBIOLOGY, 2007, 63 (03) : 724 - 736
  • [3] CHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF SPECIFIC GLYCOPROTEINS FROM TRYPANOSOMA-EQUIPERDUM VARIANTS
    BALTZ, T
    BALTZ, D
    PAUTRIZEL, R
    RICHET, C
    LAMBLIN, G
    DEGAND, P
    [J]. FEBS LETTERS, 1977, 82 (01): : 93 - 96
  • [4] Why are parasite contingency genes often associated with telomeres?
    Barry, JD
    Ginger, ML
    Burton, P
    McCulloch, R
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2003, 33 (01) : 29 - 45
  • [5] The relative significance of mechanisms of antigenic variation in African trypanosomes
    Barry, JD
    [J]. PARASITOLOGY TODAY, 1997, 13 (06): : 212 - 218
  • [6] Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeast
    Becker, M
    Aitcheson, N
    Byles, E
    Wickstead, B
    Louis, E
    Rudenko, G
    [J]. GENOME RESEARCH, 2004, 14 (11) : 2319 - 2329
  • [7] The genome of the African trypanosome Trypanosoma brucei
    Berriman, M
    Ghedin, E
    Hertz-Fowler, C
    Blandin, G
    Renauld, H
    Bartholomeu, DC
    Lennard, NJ
    Caler, E
    Hamlin, NE
    Haas, B
    Böhme, W
    Hannick, L
    Aslett, MA
    Shallom, J
    Marcello, L
    Hou, LH
    Wickstead, B
    Alsmark, UCM
    Arrowsmith, C
    Atkin, RJ
    Barron, AJ
    Bringaud, F
    Brooks, K
    Carrington, M
    Cherevach, I
    Chillingworth, TJ
    Churcher, C
    Clark, LN
    Corton, CH
    Cronin, A
    Davies, RM
    Doggett, J
    Djikeng, A
    Feldblyum, T
    Field, MC
    Fraser, A
    Goodhead, I
    Hance, Z
    Harper, D
    Harris, BR
    Hauser, H
    Hostetter, J
    Ivens, A
    Jagels, K
    Johnson, D
    Johnson, J
    Jones, K
    Kerhornou, AX
    Koo, H
    Larke, N
    [J]. SCIENCE, 2005, 309 (5733) : 416 - 422
  • [8] A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei
    Boothroyd, Catharine E.
    Dreesen, Oliver
    Leonova, Tatyana
    Ly, K. Ina
    Figueiredo, Luisa M.
    Cross, George A. M.
    Papavasiliou, F. Nina
    [J]. NATURE, 2009, 459 (7244) : 278 - U168
  • [9] Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation
    Briggs, Emma
    Crouch, Kathryn
    Lemgruber, Leandro
    Hamilton, Graham
    Lapsley, Craig
    McCulloch, Richard
    [J]. NUCLEIC ACIDS RESEARCH, 2019, 47 (17) : 9180 - 9197
  • [10] The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
    Capewell, Paul
    Cren-Travaille, Christelle
    Marchesi, Francesco
    Johnston, Pamela
    Clucas, Caroline
    Benson, Robert A.
    Gorman, Taylor-Anne
    Calvo-Alvarez, Estefania
    Crouzols, Aline
    Jouvion, Gregory
    Jamonneau, Vincent
    Weir, William
    Stevenson, M. Lynn
    O'Neill, Kerry
    Cooper, Anneli
    Swar, Nono-raymond Kuispond
    Bucheton, Bruno
    Ngoyi, Dieudonne Mumba
    Garside, Paul
    Rotureau, Brice
    MacLeod, Annette
    [J]. ELIFE, 2016, 5
12345678910