Nuclear Medicine and Wall Street: An Evolving Relationship

被引:20
作者
Sherman, Mike [1 ]
Levine, Rachel [2 ]
机构
[1] Chimerix Inc, Durham, NC USA
[2] Adv Accelerator Applicat, Commun, Millburn, NJ USA
关键词
nuclear medicine; Wall Street; radioligand therapies; Advanced Accelerator Applications; Endocyte; RADIONUCLIDE THERAPY; HISTORY;
D O I
10.2967/jnumed.118.220798
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Until recently, it has been challenging to engage Wall Street and large pharmaceutical companies in radiopharmaceutical opportunities. The modest economic prospects of most diagnostic radiopharmaceuticals have not attracted keen interest from the broader business community, despite the rapid advancement of diagnostic imaging capabilities and their increasingly crucial role in the therapeutic process. Similarly, compelling science supporting select radiopharmaceutical therapies in oncology has been overshadowed by the unique challenges posed by this class of drugs and historical commercial failures that serve as sobering reminders of risk. Fortunately, a few notable successes in the targeted radioligand therapeutic space are changing this dynamic, fueling a new flow of investor capital into these technologies and inciting increased merger and acquisition activity that has yielded significant value creation for investors. If the nuclear medicine industry is able to continue to effectively manage historical challenges, then there is significant opportunity for a new and promising wave of radioligand therapies to significantly change the oncology treatment paradigm and elevate the profile of the entire nuclear medicine sector.
引用
收藏
页码:20S / 24S
页数:5
相关论文
共 17 条
[1]  
[Anonymous], 2012, BEXX
[2]   Production of 177Lu for Targeted Radionuclide Therapy: Available Options [J].
Dash A. ;
Pillai M.R.A. ;
Knapp F.F. ;
Jr. .
Nuclear Medicine and Molecular Imaging, 2015, 49 (2) :85-107
[3]  
Hofman M, 2018, J NUCL MED, V59
[4]   Phase I/II trial of anti-PD-1 checkpoint inhibitor nivolumab and 177Lu-DOTA0-Tyr3-Octreotate for patients with extensive-stage small cell lung cancer [J].
Kim, Chul ;
Subramaniam, Deepa Suresh ;
Liu, Stephen V. ;
Giaccone, Giuseppe .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
[5]  
Lawrence S, ADV ACCELERATOR APPL
[6]   THE EARLY HISTORY OF RADIOTHERAPY - 1895-1939 [J].
LEDERMAN, M .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1981, 7 (05) :639-648
[7]   Clinical History of the Theranostic Radionuclide Approach to Neuroendocrine Tumors and Other Types of Cancer: Historical Review Based on an Interview of Eric P. Krenning by Rachel Levine [J].
Levine, Rachel ;
Krenning, Eric P. .
JOURNAL OF NUCLEAR MEDICINE, 2017, 58 :3S-9S
[8]   Manipulation of ligand binding affinity by exploitation of conformational coupling [J].
Marvin, JS ;
Hellinga, HW .
NATURE STRUCTURAL BIOLOGY, 2001, 8 (09) :795-798
[9]   Clinical development of radioimmunotherapy for B-cell non-Hodgkin's lymphoma [J].
Meredith, Ruby F. ;
Knox, Susan J. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 66 (02) :S15-S22
[10]   Guidelines for the successful generation of protein-ligand complex crystals [J].
Mueller, Ilka .
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2017, 73 :79-92