Study on the thermodynamic characteristics between fluoroquinolone and bovine serum albumin

被引：10

作者：

Guo, Ming ^{[1
]}

Lu, Wei-Jun

Yi, Ping-Gui

Yu, Qing-Sen

机构：

[1] Zhejiang Forestry Univ, Dept Chem, Linan 311300, Peoples R China

[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

JOURNAL OF CHEMICAL THERMODYNAMICS | 2007年 / 39卷 / 03期

关键词：

microcalorimetry; fluoroquinolone; bovine serum albumin; entropy-enthalpy compensation; ENTHALPY-ENTROPY COMPENSATION; TYROSINE-PHOSPHATASE; 1B; BINDING INTERACTION; MICRO-CALORIMETRY; LIGAND-BINDING; DRUGS; CIPROFLOXACIN; MOLECULES; PROTEINS; WATER;

D O I：

10.1016/j.jct.2006.08.006

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The binding reactions of the fluoroquinolone with bovine serum albumin (BSA) were investigated by microcalorimetry. The thermodynamic parameters were measured with the help of spectroscopy in a Tris-HCI buffer solution (pH 7.0, made isotonic with sodium chloride) at T = 298 K. Microcalorimetric measurements show that the molar change of enthalpy Delta H-r(m) is insignificant for the reaction, which may suggest that the interaction is governed mainly by entropy, and the iriteraction between the protein and the drugs is stronger. The results also reveal an entropy-enthalpy compensation relationship of the interaction. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：337 / 343

页数：7

共 34 条

[11] Enthalpy-entropy compensation effect in the chalcone formation from naringin in water-ethanol mixtures
González, EA
Nazareno, MA
Borsarelli, CD
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 2002, (12): : 2052 - 2056
[12] SOLVENT REORGANIZATION AND THERMODYNAMIC ENTHALPY-ENTROPY COMPENSATION
GRUNWALD, E
STEEL, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (21) : 5687 - 5692
[13] Binding interaction of gatifloxacin with bovine serum albumin
Guo, M
Zou, JW
Yi, PG
Shang, ZC
Hu, GX
Yu, QS
[J]. ANALYTICAL SCIENCES, 2004, 20 (03) : 465 - 470
[14] ATOMIC-STRUCTURE AND CHEMISTRY OF HUMAN SERUM-ALBUMIN
HE, XM
CARTER, DC
[J]. NATURE, 1992, 358 (6383) : 209 - 215
[15] PROPERTIES OF GRAPHICAL REPRESENTATIONS OF MULTIPLE CLASSES OF BINDING SITES
KLOTZ, IM
HUNSTON, DL
[J]. BIOCHEMISTRY, 1971, 10 (16) : 3065 - &
[16] STUDY OF PROTEIN DRUG-BINDING USING CAPILLARY ZONE ELECTROPHORESIS
KRAAK, JC
BUSCH, S
POPPE, H
[J]. JOURNAL OF CHROMATOGRAPHY, 1992, 608 (1-2): : 257 - 264
[17] KRAGHHANSEN U, 1981, PHARMACOL REV, V33, P17
[18] Enthalpy-entropy compensation in protein unfolding
Liu, L
Yang, C
Guo, QX
[J]. CHINESE SCIENCE BULLETIN, 2000, 45 (16): : 1476 - 1480
[19] [刘鹏 Liu Peng], 2002, [化学通报, Chemistry], V65, P682
[20] ENTHALPY-ENTROPY COMPENSATION PHENOMENA IN WATER SOLUTIONS OF PROTEINS AND SMALL MOLECULES - A UBIQUITOUS PROPERTY OF WATER
LUMRY, R
RAJENDER, S
[J]. BIOPOLYMERS, 1970, 9 (10) : 1125 - &

← 1 2 3 4 →