Amniotic Epithelial Stem Cells: Salient Features and Possible Therapeutic Role

被引:18
|
作者
Muttini, Aurelio [1 ]
Barboni, Barbara [1 ]
Valbonetti, Luca [1 ]
Russo, Valentina [1 ]
Maffulli, Nicola [2 ,3 ]
机构
[1] Univ Teramo, Fac Biosci & Technol Food Agr & Environm, Via Balzarini 1, I-64100 Teramo, Italy
[2] Univ Salerno, Sch Med & Dent, Dept Musculoskeletal Disorders, Salerno, Italy
[3] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England
来源
SPORTS MEDICINE AND ARTHROSCOPY REVIEW | 2018年 / 26卷 / 02期
关键词
amniotic epithelial cells; orthopedic regenerative medicine; immunology; tendon disorders; bone disorders; articular cartilage disorders; HUMAN FETAL MEMBRANES; REGENERATIVE MEDICINE; TRYPTOPHAN CATABOLISM; TISSUE REGENERATION; TENDON REGENERATION; PROGENITOR CELLS; TERM PLACENTA; DIFFERENTIATION; SHEEP; TENDINOPATHY;
D O I
10.1097/JSA.0000000000000189
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
This is a study of amniotic epithelial cells, which form the innermost layer of the amniotic membrane. These cells can be easily isolated and display peculiar and unique properties, such as plasticity and differentiation potential toward the 3 germinal layers, that may aid regeneration and/or repair of damaged or diseased tissues and organs. A robust literature based on in vitro, experimental, and clinical studies in large animals demonstrates that these cells can enhance the regeneration of tendons, bone, and articular cartilage. On the basis of these considerations, allotransplantation of human amniotic epithelial cells could be proposed for clinical trials in human orthopedic conditions.
引用
收藏
页码:70 / 74
页数:5
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