Structure-activity relationship of some pentacoordinated Tributyltin(IV) complexes derived from sterically hindered Schiff bases of heterocyclic ?-diketones

被引：5
作者：
Sharma, Shobhana [1 ]
机构：
[1] SS Jain Subodh P G Coll, Jaipur, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2022年 / 99卷 / 06期
关键词：
Tributyltin(IV) complexes; Schiff bases; Heterocyclic ?-diketones; Antimicrobial activity; ORGANOTIN(IV) COMPLEXES; ANTIMICROBIAL ACTIVITY; CRYSTAL; CYTOTOXICITY; CHEMISTRY; BIOCIDES;
D O I：
10.1016/j.jics.2022.100464
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some pentacoordinated tributyltin(IV) complexes of sterically hindered Schiff bases of heterocyclic beta-diketones having the general formula Bu3SnL (where LH = RC:NZC:C(OH)N(C6H5)N:CCH3 where R = -CH3, -C6H5, -C6H4Cl (p) and Z = -C6H4Cl(m), -C6H4Cl(p) and -C6H4Cl(p)] were screened for their antimicrobial activity against the bacterial strain (Bacillus subtillis) and fungal strains (Candida albicans and Aspergillas niger). These monomeric pentacoordinated tributyltin(IV) complexes possess six membered ring which provide stability to the complexes. These complexes possess Sn <- N bond scaffold which impart biological activity in tributyltin(IV) complexes. Antimicrobial bioassay results reveal that these tributyltin(IV) complexes derived from sterically hindered Schiff bases of heterocyclic beta-diketones were possess more inhibition potential than their respective parent ligands. These pentacoordinated tributyltin(IV) complexes may used as antibiotic drug in future.
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页数：4
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