Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects

被引：63

作者：

Bianchin, Marino Muxfeldt ^{[1
]}

Londero, Renata Gomes ^{[2
]}

Lima, Jose Eduardo ^{[3
]}

Bigal, Marcelo Eduardo ^{[4
,5
]}

机构：

[1] Univ Fed Rio Grande do Sul, Div Neurol, Hosp Clin Porto Alegre, BR-90035903 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Med Sci Postgrad Program, BR-90035903 Porto Alegre, RS, Brazil

[3] Univ Fed Sao Carlos, Dept Med, Sch Med, BR-13560 Sao Carlos, SP, Brazil

[4] Merck Res Labs, Sci Affairs Neurol & Psychiat, Upper Gwynedd, PA USA

[5] Albert Einstein Coll Med, Dept Neurol, New York, NY USA

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2010年 / 14卷 / 04期

关键词：

Comorbidity; Headache; Migraine; Epilepsy; Paroxysmal disorders; CORTICAL SPREADING DEPRESSION; CHILDHOOD OCCIPITAL EPILEPSY; FAMILIAL HEMIPLEGIC MIGRAINE; PERI-ICTAL HEADACHE; BRAIN-STEM; EPISODIC ATAXIA; GLOBAL BURDEN; RISK-FACTORS; MUTATIONS; SPECTRUM;

D O I：

10.1007/s11916-010-0121-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The association of epilepsy and migraine has been long recognized. Migraine and epilepsy are both chronic disorders with episodic attacks. Furthermore, headache may be a premonitory or postdromic symptom of seizures, and migraine headaches may cause seizures per se (migralepsy). Migraine and epilepsy are comorbid, sharing pathophysiological mechanisms and common clinical features. Several recent studies identified common genetic and molecular substrates for migraine and epilepsy, including phenotypic-genotypic correlations with mutations in the CACNA1A, ATP1A2, and SCN1A genes, as well as in syndromes due to mutations in the SLC1A3, POLG, and C10orF2 genes. Herein, we review the relationship between migraine and epilepsy, focusing on clinical aspects and some recent pathophysiological and molecular studies.

引用

页码：276 / 283

页数：8

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