A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

被引：198

作者：

Larisch, S

Yi, YS

Lotan, R

Kerner, H

Eimerl, S

Parks, WT

Gottfried, Y

Reffey, SB

de Caestecker, MP

Danielpour, D

Book-Melamed, N

Timberg, R

Duckett, CS

Lechleider, RJ

Steller, H

Orly, J

Kim, SJ

Roberts, AB ^{[1
]}

机构：

[1] NCI, Lab Cell Regulat & Carcinogenesis, NIH, Bethesda, MD 20892 USA

[2] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA

[3] Rambam Med Ctr, Dept Pathol, Haifa, Israel

[4] Hebrew Univ Jerusalem, Dept Biol Chem, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel

[5] Case Western Reserve Univ, Ctr Canc, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA

[7] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 12期

基金：

美国国家卫生研究院; 以色列科学基金会;

关键词：

D O I：

10.1038/35046566

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.

引用

页码：915 / 921

页数：7

共 42 条

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