Copper-Catalyzed N-Arylation with Boronic Acid Pinacol Esters

被引：13
|
作者：
Liu, Shuai [1 ]
Xu, Liang [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 09期
基金：
中国国家自然科学基金;
关键词：
N-arylation; C-N cross-coupling; Chelation assistance; boronic pinacol esters; CROSS-COUPLING REACTIONS; C-H AMIDATION; ROOM-TEMPERATURE; PALLADIUM; AMINATION; ARYL; ALKYNYLATION; ETHERS;
D O I：
10.1002/ajoc.201800371
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed facile N-arylation of 2-acyl substituted anilines has been disclosed. Through chelation assistance of the weakly coordinating carbonyl groups, the Chan-Evans-Lam (CEL) C-N cross-coupling reactions proceeded at room temperature in open flasks. Furthermore, such chelation effects also enabled the direct utilization of aryl boronic acid pinacol esters in Cu-catalyzed CEL reactions under mild conditions.
引用
收藏
页码：1856 / 1863
页数：8
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