Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials

被引：30

作者：

Zoccali, Carmine ^{[1
]}

Blankestijn, Peter J. ^{[2
]}

Bruchfeld, Annette ^{[3
]}

Capasso, Giovambattista ^{[4
]}

Fliser, Danilo ^{[5
]}

Fouque, Denis ^{[6
]}

Goumenos, Dimitrios ^{[7
]}

Ketteler, Markus ^{[8
]}

Massy, Ziad ^{[9
]}

Rychlik, Ivan ^{[10
]}

Jose Soler, Maria ^{[11
]}

Stevens, Kate ^{[12
]}

Spasovski, Goce ^{[13
]}

Wanner, Christoph ^{[14
]}

机构：

[1] Osped Riuniti Reggio Calabria, CNR IFC, Reggio Di Calabria, Italy

[2] Univ Med Ctr, Dept Nephrol, Utrecht, Netherlands

[3] Karolinska Univ Hosp, Dept Renal Med, Stockholm, Sweden

[4] Univ Campania Luigi Vanvitelli, Dept Nephrol, Naples, Italy

[5] Univ Med Ctr, Internal Med Renal & Hypertens Dis 4, Homburg, Germany

[6] Ctr Hosp Lyon Sud, Dept Nephrol Dialysis Nutr, Pierre Banite, France

[7] Patras Univ Hosp, Dept Nephrol & Renal Transplantat, Patras, Greece

[8] Nephrol Klin Klinikum Coburg, Coburg, Germany

[9] Paris Ile de France West Univ UVSQ, Ambroise Pare Hosp, Div Nephrol, Villejuif, France

[10] Charles Univ Prague, Fac Med 3, Dept Internal Med 1, Prague, Czech Republic

[11] Hosp Univ Vall dHebron, Dept Nephrol, Vall dHebron Res Inst VHIR, Nephrol Res Grp, Barcelona, Spain

[12] Queen Elizabeth Univ Hosp, Glasgow Renal & Transplant Unit, Glasgow, Lanark, Scotland

[13] Univ Skopje, Med Fac, Dept Nephrol, Skopje, North Macedonia

[14] Univ Wurzburg, Div Nephrol, Wurzburg, Germany

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2019年 / 34卷 / 07期

关键词：

cardiovascular; CKD; clinical trial; diabetes mellitus; guidelines; CANCER; REPRESENTATION; OUTCOMES;

D O I：

10.1093/ndt/gfz023

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.

引用

页码：1112 / 1114

页数：3

共 50 条

[21] Clinical Management of Chronic Kidney Disease Patients in Italy: Results from the IRIDE Study [J].

Cozzolino, Mario ;

Bolasco, Piergiorgio ;

Ronco, Claudio ;

Conte, Giuseppe ;

Mene, Paolo ;

Mereu, Maria Cristina ;

Di Luca, Marina ;

Roccatello, Dario ;

Rosati, Alberto ;

Jommi, Claudio ;

Costanzo, Anna Maria ;

Gualberti, Giuliana ;

Paparatti, Umberto di Luzio ;

Remuzzi, Giuseppe .

NEPHRON, 2018, 140 (01) :39-47

[22] Integrating liver endpoints in clinical trials of cardiovascular and kidney disease [J].

Zannad, Faiez ;

Sanyal, Arun J. ;

Butler, Javed ;

Miller, Veronica ;

Harrison, Stephen A. .

NATURE MEDICINE, 2024, 30 (09) :2423-2431

[23] TREATMENT WITH PARICALCITOL: CLINICAL IMPLICATIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE [J].

Tanasescu, Maria-Daniela ;

Rosu, Andrei-Mihnea ;

Turlacu, Malina-Gabriela ;

Ion, Laurentiu-Cristian ;

Minca, Alexandru ;

Rosu, Andreea-Liana ;

Ionita, Elena Iuliana ;

Timofte, Delia ;

Ionescu, Dorin .

FARMACIA, 2025, 73 (03) :535-541

[24] Clinical course of lung cancer in patients with chronic kidney disease [J].

Patel, P ;

Henry, LL ;

Ganti, AK ;

Potti, A .

LUNG CANCER, 2004, 43 (03) :297-300

[25] Clinical policies on the management of chronic kidney disease patients in Italy [J].

Locatelli, Francesco ;

Zoccali, Carmine .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (02) :621-626

[26] Risk factors for progression of chronic kidney disease in the EPPIC trials and the effect of AST-120 [J].

Schulman, Gerald ;

Berl, Tomas ;

Beck, Gerald J. ;

Remuzzi, Giuseppe ;

Ritz, Eberhard ;

Shimizu, Miho ;

Kikuchi, Mami ;

Shobu, Yuko .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2018, 22 (02) :299-308

[27] Dietary acid load in children with chronic kidney disease [J].

Lopez, Michelle ;

Moreno, Greysi ;

Lugo, Gustavo ;

Marcano, Gilmary .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2020, 74 (Suppl 1) :57-62

[28] Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey [J].

Farisco, Michele ;

Blumblyte, Inga A. ;

Franssen, Casper ;

Nitsch, Dorothea ;

Zecchino, Irene ;

Capasso, Giovambattista ;

Hafez, Gaye .

CLINICAL KIDNEY JOURNAL, 2024, 17 (05)

[29] Cardiovascular disease in children with chronic kidney disease [J].

Kouri, Anne M. ;

Rheault, Michelle N. .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2021, 30 (02) :231-236

[30] Epidemiology of Chronic Kidney Disease in Children: A Report from Lithuania [J].

Masalskiene, Jurate ;

Rudaitis, Sarunas ;

Vitkevic, Renata ;

Cerkauskiene, Rimante ;

Dobiliene, Diana ;

Jankauskiene, Augustina .

MEDICINA-LITHUANIA, 2021, 57 (02)

← 1 2 3 4 5 →