Novel synthons from mucochloric acid:: The first use of α,β-dichloro-γ-butenolides and γ-butyrolactams for direct vinylogous aldol addition

被引：24

作者：

Das Sarma, Koushik ^{[1
]}

Zhang, Ji ^{[1
]}

Curran, Timothy T. ^{[1
]}

机构：

[1] Pfizer Inc, Ann Arbor Labs, Res API, Pfizer Global RRes & Dev, Ann Arbor, MI 48105 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 09期

关键词：

D O I：

10.1021/jo062613l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 5-(1'-hydroxy)-gamma-butyrolactone and gamma-butyrolactam subunits were synthesized by direct vinylogous aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams with aldehydes under basic conditions. Different bases and solvents were screened in the context of generating gamma-butyrolactones. Diastereoselectivity was observed and gamma-butenolides and gamma-butyrolactams showed opposite diastereoselectivity under the same reaction condition.

引用

页码：3311 / 3318

页数：8

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