Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report

被引：23
作者：
Ji, Guanghui [1 ]
Hong, Liu [2 ]
Yang, Ping [3 ]
机构：
[1] Navy Gen Hosp, Dept Tradit Chinese Med, Beijing 100048, Peoples R China
[2] Navy Gen Hosp, Dept Pathol, Beijing 100048, Peoples R China
[3] Navy Gen Hosp, Dept Oncol, 6 Fucheng Rd, Beijing 100048, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2016年 / 9卷
关键词：
malignant fibrous histiocytoma; apatinib; chemotherapy; angiogenesis inhibitor; targeted therapy; PHASE-II TRIAL; SOFT-TISSUE SARCOMA; 2ND-LINE CHEMOTHERAPY; TYROSINE KINASE; GEMCITABINE; DOCETAXEL; DOXORUBICIN; IFOSFAMIDE; INHIBITOR; YN968D1;
D O I：
10.2147/OTT.S96133
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Malignant fibrous histiocytoma (MFH) is the most common soft-tissue sarcoma in late adult life. Unfortunately, advanced MFH has a poor prognosis due to a lack of effective drugs. We present here a case of advanced MFH with partial response to apatinib, a new potent oral small-molecule tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2). To the best of our knowledge, this is the first case report using apatinib for MFH. Quantitative polymerase chain reaction analysis revealed high expression of VEGFR-2 mRNA, suggesting that apatinib leads to clinical response by inhibiting VEGFR-2 tyrosine kinase activity and the crucial role of VEGFR-2 for MFH. Apatinib could be a new option for the treatment of MFH. Further studies are needed to optimize the treatment.
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收藏
页码：643 / 647
页数：5
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