A depsidone and six triterpenoids from the bark of Garcinia celebica

被引：22

作者：

Bui, Thai Q. ^{[1
,2
]}

Bui, An T. ^{[1
]}

Nguyen, Kien T. ^{[1
]}

Nguyen, Vy T. ^{[3
]}

Trinh, Binh T. D. ^{[1
]}

Nguyen, Lien-Hoa D. ^{[1
,2
]}

机构：

[1] VNUHCM Univ Sci, Fac Chem, Nat Prod & Med Chem Lab, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam

[2] VNUHCM Univ Sci, Fac Chem, Dept Organ Chem, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam

[3] VNUHCM Univ Sci, Fac Biol & Biotechnol, Dept Genet, Mol Biol Lab, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 23期

关键词：

Garcinia celebica; Structural elucidation; Depsidone; Xanthones; Lanostanes and friedolanostanes; Cytotoxicity; CYTOTOXIC XANTHONES; STEM BARK; FRIEDOLANOSTANES; LANOSTANES; CONSTITUENTS;

D O I：

10.1016/j.tetlet.2016.04.104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new depsidone, garcinisidone H (1), and six novel triterpenoids, were isolated from the bark of Garcinia celebica. The latter compounds consisted of two lanostanes, (E)-30,9 alpha-dihydroxylanosta-24-en-26-oic acid (2) and 3,23-dioxo-9,16-lanostadien-26-oic acid (3), and four friedolanostanes, (24E)-3-oxo-17,14-friedolanosta-8,14,24-trien-26-oic acid (4), (22Z,24E)-9 alpha-hydroxy-3-oxo-17,13-friedolanosta-12,22,24-trien-26-oic acid (5), (22Z,24E)-3-oxo-17,14-friedolanosta-8,14,22,24-tetraen-26-oic acid (6) and (22Z,24E)-9 alpha-hydroxy-3-oxo-13 alpha,30-cyclo-17,13-friedolanosta-22,24-dien-26-oic acid (7). In addition, twelve known compounds were obtained. The structures of the new compounds were elucidated using spectroscopic methods, mainly 1D and 2D NMR. The cytotoxicity of the isolated compounds against the human breast cancer cell line MCF-7 was evaluated using the sulforhodamine B assay, in which macluraxanthone exhibited the strongest activity with an IC50 of 6.1 mu M. (C) 2016 Published by Elsevier Ltd.

引用

页码：2524 / 2529

页数：6

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