A Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals

被引：25
作者：
Delgado-Bermudez, Ariadna [1 ,2 ]
Yeste, Marc [1 ,2 ,3 ]
Bonet, Sergi [1 ,2 ]
Pinart, Elisabeth [1 ,2 ]
机构：
[1] Univ Girona, Inst Food & Agr Technol, Biotechnol Anim & Human Reprod TechnoSperm, ES-17003 Girona, Spain
[2] Univ Girona, Fac Sci, Dept Biol, Unit Cell Biol, ES-17003 Girona, Spain
[3] Catalan Inst Res & Adv Studies ICREA, ES-08010 Barcelona, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 11期
关键词：
HVCN1; channels; SLC4; SLC26; NHE; sperm capacitation; mammals; TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE-CAUSING MUTATIONS; SOLUBLE ADENYLYL-CYCLASE; NA+/H+ EXCHANGER; ANION TRANSPORTERS; GENE FAMILY; CARBONIC-ANHYDRASES; ERYTHROCYTE BAND-3; CL-/HCO3-EXCHANGER; HUMAN SPERMATOZOA;
D O I：
10.3390/ijms23116333
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alkalinization of sperm cytosol is essential for plasma membrane hyperpolarization, hyperactivation of motility, and acrosomal exocytosis during sperm capacitation in mammals. The plasma membrane of sperm cells contains different ion channels implicated in the increase of internal pH (pH(i)) by favoring either bicarbonate entrance or proton efflux. Bicarbonate transporters belong to the solute carrier families 4 (SLC4) and 26 (SLC26) and are currently grouped into Na+/HCO3- transporters and Cl-/HCO3- exchangers. Na+/HCO3- transporters are reported to be essential for the initial and fast entrance of HCO3- that triggers sperm capacitation, whereas Cl-/HCO3- exchangers are responsible for the sustained HCO3- entrance which orchestrates the sequence of changes associated with sperm capacitation. Proton efflux is required for the fast alkalinization of capacitated sperm cells and the activation of pH-dependent proteins; according to the species, this transport can be mediated by Na+/H+ exchangers (NHE) belonging to the SLC9 family and/or voltage-gated proton channels (HVCN1). Herein, we discuss the involvement of each of these channels in sperm capacitation and the acrosome reaction.
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页数：20
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