Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium

被引：119

作者：

Valdes, Cecilia T. ^{[1
]}

Schutt, Amy ^{[1
]}

Simon, Carlos ^{[1
,2
,3
,4
,5
]}

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[2] Univ Valencia, Dept Obstet & Gynecol, Valencia, Spain

[3] INCLIVA, Valencia, Spain

[4] Parc Cient Valencia Univ, Igenomix, Valencia, Spain

[5] Stanford Univ, Dept Obstet & Gynecol, Stanford, CA 94305 USA

来源：

FERTILITY AND STERILITY | 2017年 / 108卷 / 01期

关键词：

Repeated implantation failure; desynchronization; endometrial dysfunction; endometrial receptivity analysis; personalized embryo transfer; IN-VITRO FERTILIZATION; ADVANCED MATERNAL AGE; GENE-EXPRESSION; MENSTRUAL-CYCLE; PREGNANCY RATES; WOMEN; PREVALENCE; DIAGNOSIS; DAY-5; DONOR;

D O I：

10.1016/j.fertnstert.2017.05.033

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Repeated implantation failure (RIF) is an intriguing, massive failure of reproductive treatment in otherwise healthy women leading to the introduction of empirical adjuvant interventions that are costly, inefficient, and frustrating for our patients. In this article, we will try to convince the readers that RIF is neither a stigma nor a mysterious pathology but rather our failure to diagnose and properly synchronize the euploid blastocyst with the patient's personalized window of implantation. (Fertil Steril((R)) 2017;108:15-8. (C) 2017 by American Society for Reproductive Medicine.)

引用

页码：15 / 18

页数：4

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