An Efficient and Clean Synthesis of Pyrido[2,3-d]pyrimidine-4,7-dione Derivatives in Aqueous Media

被引：21

作者：

Shi, Da-Qing ^{[1
]}

Shi, Jing-Wen ^{[2
]}

Rong, Shao-Feng ^{[2
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Xuzhou Normal Univ, Coll Chem & Chem Engn, Xuzhou 221116, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 06期

关键词：

ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; CONDENSATION REACTION; 3-COMPONENT REACTION; PYRIMIDINE; ANALOGS; WATER; BOND; CYCLOADDITION; INHIBITORS;

D O I：

10.1002/jhet.223

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-amino-5-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives were synthesized via the three-component reaction of aromatic aldehyde, 2,6-diaminopyrimidine- 4(3H)-one, and Meldrum's acid in water in the presence of triethylbenzylammonium chloride (TEBAC). This protocol has the advantages of easier work-up, milder reaction conditions, and environmentally benign procedure.

引用

页码：1331 / 1334

页数：4

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