Characterization of Idiopathic Choroidal Neovascularization Using Fluorescein Angiography, Indocyanine Green Angiography, and Optical Coherence Tomography Angiography

BACKGROUND AND OBJECTIVE: To assess the usefulness of optical coherence tomography angiography (OCTA) in cases of idiopathic choroidal neovascularization (iCNV). PATIENTS AND METHODS: Seven eyes with suspected iCNV were evaluated using OCT, OCTA, fluorescein angiography (FA), and indocyanine green angiography (ICGA) and were followed up between 3 weeks and 4 weeks following an intravitreal anti-vascular endothelial growth factor (VEGF) injection. The utility of OCTA in the diagnosis and characterization of morphology of iCNV at baseline and follow-up was assessed. RESULTS: Morphology of vasculature comprising iCNV could be detected in all cases (100%) on OCTA and in 57% cases on ICGA. FA only detected hyperfluorescence and not individual vessel morphology. After anti-VEGF injection, the mean logMAR visual acuity improved from 0.55 to 0.27. A qualitative scale to assess response of therapy is suggested. CONCLUSIONS: OCTA is a useful, noninvasive tool to detect, characterize, and follow-up on cases of suspected iCNV with utility comparable to or even better than traditional angiography techniques.