Comprehensive analysis of proteins secreted by Trichophyton rubrum and Trichophyton violaceum under in vitro conditions

被引：47

作者：

Giddey, Karin

Monod, Michel

Barblan, Jachen

Potts, Alexandra

Waridel, Patrice

Zaugg, Christophe

Quadroni, Manfredo ^{[1
]}

机构：

[1] Univ Lausanne, Ctr Integrat Genom, Prot Anal Facil, Lausanne, Switzerland

[2] Univ Vaudois, Ctr Hosp, Serv Dermatol & Venereol, Lausanne, Switzerland

来源：

JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 08期

关键词：

dermatophyte; secreted proteins; secretome; two-dimensional electrophoresis; tandem mass spectrometry; expressed sequence tags;

D O I：

10.1021/pr070153m

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dermatophytes cause most superficial mycoses in humans and animals. Their pathogenicity is probably linked with the secretion of proteins degrading keratinised structures. Using 2D-PAGE and a shotgun mass spectrometry approach, we identified 80 proteins from Trichophyton rubrum and Trichophyton violaceum secretomes, under conditions mimicking those in the host. Identified proteins included endo- and exoproteases, other hydrolases, and oxidoreductases. Our findings can contribute to a better understanding of the virulence mechanisms of the two species and the different types of infection they cause.

引用

页码：3081 / 3092

页数：12

共 44 条

[1] Proteome of conidial surface associated proteins of Aspergillus fumigatus reflecting potential vaccine candidates and allergens [J].