Dominant negative c-Jun inhibits platelet-derived growth factor-directed migration by vascular smooth muscle cells

被引：0
作者：
Ioroi, T
Yamamori, M
Yagi, K [1 ]
Hirai, M
Zhan, Y
Kim, S
Iwao, H
机构：
[1] Kobe Pharmaceut Univ, Dept Clin Pharm, Kobe, Hyogo 6588558, Japan
[2] Osaka City Univ, Sch Med, Dept Pharmacol, Osaka 5458585, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2003年 / 91卷 / 02期
关键词：
cell migration; vascular smooth muscle cell; gene transfer;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The mitogen-activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood. In this study, we investigated the possible contribution of signaling pathways through c-Jun in platelet-derived growth factor (PDGF)-BB directed cell migration in rat aortic vascular smooth muscle cells (VSMCs) infected with a recombinant adenovirus containing the dominant-negative c-Jun (Ad-DN-c-Jun). DN-c-Jun protein was expressed dose-dependently in VSMCs infected with Ad-DN-c-Jun. Expression of DN-c-Jun significantly inhibited VSMC migration induced by PDGF-BB. Our results provide the first evidence that signaling pathways through c-Jun participates in cell migration induced by PDGF-BB in addition to other MAP kinase pathways in VSMCs.
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收藏
页码：145 / 148
页数：4
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