Dominant negative c-Jun inhibits platelet-derived growth factor-directed migration by vascular smooth muscle cells

被引：0

作者：

Ioroi, T

Yamamori, M

Yagi, K ^{[1
]}

Hirai, M

Zhan, Y

Kim, S

Iwao, H

机构：

[1] Kobe Pharmaceut Univ, Dept Clin Pharm, Kobe, Hyogo 6588558, Japan

[2] Osaka City Univ, Sch Med, Dept Pharmacol, Osaka 5458585, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2003年 / 91卷 / 02期

关键词：

cell migration; vascular smooth muscle cell; gene transfer;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mitogen-activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood. In this study, we investigated the possible contribution of signaling pathways through c-Jun in platelet-derived growth factor (PDGF)-BB directed cell migration in rat aortic vascular smooth muscle cells (VSMCs) infected with a recombinant adenovirus containing the dominant-negative c-Jun (Ad-DN-c-Jun). DN-c-Jun protein was expressed dose-dependently in VSMCs infected with Ad-DN-c-Jun. Expression of DN-c-Jun significantly inhibited VSMC migration induced by PDGF-BB. Our results provide the first evidence that signaling pathways through c-Jun participates in cell migration induced by PDGF-BB in addition to other MAP kinase pathways in VSMCs.

引用

页码：145 / 148

页数：4

共 15 条

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