Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

被引：1
作者：
Mundra, Sourabh [1 ]
Mahesh, Radhakrishnan [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Pharm, FD-3, Pilani 333031, Rajasthan, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 05期
关键词：
5-Carboethoxy-2-thiouracil; Thiourea; Pyrimidine; Microwave irradiation; Synthesis; DIASTEREOSELECTIVE SYNTHESIS; CONDENSATION REACTION; EFFICIENT SYNTHESIS; THERMAL-BEHAVIOR; PTC ALKYLATION; COMPLEXES; DERIVATIVES; ISOOROTATE; PALLADIUM; TRIFLATE;
D O I：
10.1007/s11164-015-2270-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pyridine has been used for one-pot, two-component synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives in moderate to good yields by condensing N-substituted thioureas with diethyl ethoxymalonate under microwave irradiation.
引用
收藏
页码：4207 / 4219
页数：13
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