Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

被引：1

作者：

Mundra, Sourabh ^{[1
]}

Mahesh, Radhakrishnan ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Pharm, FD-3, Pilani 333031, Rajasthan, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 05期

关键词：

5-Carboethoxy-2-thiouracil; Thiourea; Pyrimidine; Microwave irradiation; Synthesis; DIASTEREOSELECTIVE SYNTHESIS; CONDENSATION REACTION; EFFICIENT SYNTHESIS; THERMAL-BEHAVIOR; PTC ALKYLATION; COMPLEXES; DERIVATIVES; ISOOROTATE; PALLADIUM; TRIFLATE;

D O I：

10.1007/s11164-015-2270-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyridine has been used for one-pot, two-component synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives in moderate to good yields by condensing N-substituted thioureas with diethyl ethoxymalonate under microwave irradiation.

引用

页码：4207 / 4219

页数：13

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