Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives

被引：8

作者：

Finotti, Michele ^{[1
]}

Romano, Maurizio ^{[1
]}

Auricchio, Pasquale ^{[2
]}

Scopelliti, Michele ^{[1
]}

Brizzolari, Marco ^{[1
]}

Grossi, Ugo ^{[1
]}

Piccino, Marco ^{[1
]}

Benvenuti, Stefano ^{[3
]}

Morana, Giovanni ^{[4
]}

Cillo, Umberto ^{[2
]}

Zanus, Giacomo ^{[1
]}

机构：

[1] Univ Padua, Reg Hosp Treviso, Surg Unit 4, DISCOG, I-31100 Padua, Italy

[2] Univ Padua, Hepatobiliary Surg & Liver Transplantat Unit, DISCOG, I-35121 Padua, Italy

[3] Ca Foncello Reg Hosp, Gastroenterol Unit 4, I-31100 Treviso, Italy

[4] Treviso Reg Hosp, Div Radiol, I-31100 Treviso, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 06期

关键词：

non-alcoholic fatty liver disease; liver transplantation; bariatric surgery; FATTY LIVER-DISEASE; TYPE-2; DIABETES-MELLITUS; PORTAL-VEIN THROMBOSIS; CORONARY-HEART-DISEASE; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; CRYPTOGENIC CIRRHOSIS; VITAMIN-E; HEPATOCELLULAR-CARCINOMA; URSODEOXYCHOLIC ACID;

D O I：

10.3390/jpm11060499

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the severity of their disease to tailor the available treatments. In our contribution, we review the most recent pharmacological target therapies, the role of bariatric surgery, and the impact of liver transplantation on the NAFLD outcome.

引用

页数：19