A Combinational Approach for More Efficient miRNA Biosensing

被引：4

作者：

Lee, Cheolho ^{[1
]}

机构：

[1] Seokyeong Univ, Dept Chem & Biol Engn, Seoul, South Korea

来源：

CURRENT GENOMICS | 2022年 / 23卷 / 01期

关键词：

miRNA detection system; biosensing platform; next-generation miRNA biosensing; miRNAs; nanomaterial-based miRNA; nucleic acid amplification; DUPLEX-SPECIFIC NUCLEASE; ROLLING-CIRCLE AMPLIFICATION; RESONANCE ENERGY-TRANSFER; HYBRIDIZATION CHAIN-REACTION; GRAPHENE QUANTUM DOTS; SENSITIVE DETECTION; SIGNAL AMPLIFICATION; MICRORNA DETECTION; LABEL-FREE; ELECTROCHEMICAL BIOSENSOR;

D O I：

10.2174/1389202923666220204160912

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs, short single-stranded noncoding RNAs ranging in length from 18 similar to 24 bp, are found in all kingdoms of eukaryotes and even viruses. It was found that miRNAs are involved in a variety of biological processes, and their intracellular aberrant expression is related to diseases and abnormalities in the immune system. Since then, it has been considered essential to develop an efficient miRNA detection system. In this review, the limitations of traditional scheme-based miRNA detection methods are compared and analyzed. In particular, nucleic acid amplification-based miRNA detection methods and nanomaterial-based miRNA detection methods, which are widely used as a biosensing platform because of various features and advantages, such as high sensitivity, specificity, and simplicity, are analyzed. Based on this analysis, the latest examples of a combination of the advantages of nucleic acid amplification and those of nanomaterials are examined to suggest the characteristics of the next-generation miRNA biosensing.

引用

页码：5 / 25

页数：21

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