MCP-induced protein 1 suppresses TNFα-induced VCAM-1 expression in human endothelial cells

被引：40
|
作者：
Qi, Yongfen [3 ,4 ]
Liang, Jian [3 ]
She, Zhi-Gang [5 ]
Cai, Yan [4 ]
Wang, Jing [3 ]
Lei, Tianhua [3 ]
Stallcup, William B. [5 ]
Fu, Mingui [1 ,2 ,3 ]
机构：
[1] Univ Missouri, Sch Med, Shock Trauma Res Ctr, Kansas City, MO 64108 USA
[2] Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA
[3] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA
[4] Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100192, Peoples R China
[5] Sanford Burnham Med Res Inst, Ctr Canc, La Jolla, CA USA
来源：
FEBS LETTERS | 2010年 / 584卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MCPIP1; Endothelial cell; Inflammation; NF-kappa B signaling; Adhesion molecule; MONOCYTE CHEMOATTRACTANT PROTEIN-1; KAPPA-B; PROINFLAMMATORY ACTIVATION; TRANSCRIPTION FACTOR; MESSENGER-RNA; ATHEROSCLEROSIS; REGULATOR; REVEALS; MICE;
D O I：
10.1016/j.febslet.2010.05.040
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We here report that treatment of human umbilical vein endothelial cells (HUVECs) with tumor necrosis factor (TNF) alpha substantially increased the expression of MCP-induced protein 1 (MCPIP1). Overexpression of MCPIP1 protected ECs against TNF alpha-induced endothelial activation, as characterized by the attenuation in the expression of the adhesion molecule VCAM-1 and monocyte adherence to ECs. Conversely, small interfering RNA-mediated knock down of MCPIP1 increased the expression of VCAM-1 and monocytic adherence to ECs. These studies identified MCPIP1 as a feedback control of cytokines-induced endothelial inflammation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3065 / 3072
页数：8
相关论文
共 50 条
  • [41] Niacin inhibits LDL oxidation and redox-sensitive VCAM-1 and MCP-1 expression in human aortic endothelial cells
    Ganji, SH
    Qin, SC
    Liu, TJ
    Kamanna, VS
    Kashyap, ML
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (05) : E75 - E75
  • [42] AGE, but not high glucose stimulate the expression of VCAM-1 in human endothelial cells
    Rosen, E
    Sui, GZ
    Du, XL
    Bunting, C
    Koschinsky, T
    DIABETES, 1999, 48 : A32 - A32
  • [43] TNF ALPHA-INDUCED EXPRESSION OF ENDOTHELIAL ADHESION MOLECULES, ICAM-1 AND VCAM-1, IS LINKED TO PROTEIN-KINASE-C ACTIVATION
    MATTILA, P
    MAJURI, ML
    MATTILA, PS
    RENKONEN, R
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1992, 36 (02) : 159 - 165
  • [44] A benzothiophene-carboxamide is a potent inhibitor of IL-1 beta induced VCAM-1 gene expression in human endothelial cells
    Cobb, RR
    Felts, KA
    McKenzie, TC
    Parry, GCN
    Mackman, N
    FEBS LETTERS, 1996, 382 (03) : 323 - 326
  • [45] Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells
    Vandermeeren, M
    Janssens, S
    Borgers, M
    Geysen, J
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 234 (01) : 19 - 23
  • [46] ApoM Suppresses TNF-α-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-κB
    Gao, Ji-Juan
    Hu, Yan-Wei
    Wang, Yan-Chao
    Sha, Yan-Hua
    Ma, Xin
    Li, Shu-Fen
    Zhao, Jia-Yi
    Lu, Jing-Bo
    Huang, Chuan
    Zhao, Jing-Jing
    Zheng, Lei
    Wang, Qian
    DNA AND CELL BIOLOGY, 2015, 34 (08) : 550 - 556
  • [47] IL-17 reduces TNF-induced rantes and VCAM-1 expression
    Schnyder, B
    Schnyder-Candrian, S
    Pansky, A
    Schmitz, ML
    Heim, M
    Ryffel, B
    Moser, R
    CYTOKINE, 2005, 31 (03) : 191 - 202
  • [48] TGF-BETA-1 DECREASES TNF-INDUCED MCP-1 EXPRESSION BY HUMAN ENDOTHELIAL-CELLS
    CUFF, CA
    BROSNAN, CF
    BERMAN, JW
    FASEB JOURNAL, 1995, 9 (03): : A198 - A198
  • [49] Androgen exposure increases VCAM-1 surface expression and VCAM message transcription in human endothelial cells
    Sader, MA
    McCrohon, JA
    Death, AK
    Jessup, W
    Celermajer, DS
    CIRCULATION, 1999, 100 (18) : 639 - 640
  • [50] Isobavachalcone attenuates TNF-α-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells by regulating the NF-κB signaling pathway
    Ae Sin Lee
    Jinyoung Hur
    Sang Yoon Choi
    Applied Biological Chemistry, 2022, 65
12345