A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants

被引：254
作者：
Anandalakshmi, R
Marathe, R
Ge, X
Herr, JM
Mau, C
Mallory, A
Pruss, G
Bowman, L
Vance, VB [1 ]
机构：
[1] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA
[2] Univ Calif Davis, CEPRAP, Davis, CA 95616 USA
来源：
SCIENCE | 2000年 / 290卷 / 5489期
关键词：
D O I：
10.1126/science.290.5489.142
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Posttranscriptional gene silencing (PTGS) is an ancient eukaryotic regulatory mechanism in which a particular RNA sequence is targeted and destroyed. The helper component-proteinase (HC-Pro) of plant potyviruses suppresses PTGS in plants; Using a yeast two-hybrid system, we identified a calmodulin-related protein (termed rgs-CaM) that interacts with HC-Pro. Here we report that rgs-CaM, like HC-Pro itself, suppresses gene silencing. Our work is the first report identifying a cellular suppressor of PTGS.
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页码：142 / 144
页数：3
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