Delivery of cisplatin by folic acid-targeted liposomal nanoparticles into liver cancer cell line

被引：10

作者：

Foroud, Niki ^{[1
]}

Ardjmand, Mehdi ^{[2
]}

Heidarinasab, Amir ^{[1
]}

Akbarzadeh, Azim ^{[3
]}

机构：

[1] Islamic Azad Univ, Sci & Res Branch, Dept Chem Engn, Tehran, Iran

[2] Islamic Azad Univ, South Tehran Branch, Chem Engn Dept, Tehran, Iran

[3] Pasteur Inst Iran, Dept Pilot Nanobiotechnol, Tehran 1316943551, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 14期

关键词：

Cisplatin; folic acid; liposome; liver cancer; polyethylene glycol; CYANOACRYLATE NANOPARTICLES; MULTIDRUG-RESISTANCE; ENCAPSULATION; ANTICANCER; EFFICIENCY; EFFICACY; DRUGS;

D O I：

10.1080/00914037.2017.1393676

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This study aimed to prepare cisplatin-loaded PEGylated liposomal nanoparticles targeted with folic acid and evaluate their efficacy on liver cancer cell line PLC/PRF/5 (Alexander hepatoma cell line). Nanoparticles were prepared by reverse phase evaporation technique and characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy, inductively coupled plasma optical emission spectrometry, Fourier transform infrared spectroscopy, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide techniques. Nanoscale particles with appropriate drug encapsulation efficiency (13%) were prepared. Cytotoxicity results indicated that the superior potency of targeted cisplatin-loaded nanoparticles compared to the nontargeted counterpart with 23% more cytotoxicity. Findings of this study confirmed the potency of targeted PEGylated liposomal nanoparticles. [GRAPHICS] .

引用

页码：865 / 872

页数：8

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