Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

被引：219

作者：

Moradi, Shayli Varasteh ^{[1
]}

Hussein, Waleed M. ^{[1
]}

Varamini, Pegah ^{[1
]}

Simerska, Pavla ^{[1
]}

Toth, Istvan ^{[1
,2
,3
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[3] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 04期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

ANALOGS PRODUCE ANALGESIA; N-LINKED GLYCOSYLATION; CHEMOENZYMATIC SYNTHESIS; ENZYMATIC GLYCOSYLATION; GLUCOSE TRANSPORTERS; BIOLOGICAL-ACTIVITY; HORMONE ANALOGS; RECENT PROGRESS; DRUG-DELIVERY; ORAL DELIVERY;

D O I：

10.1039/c5sc04392a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein.

引用

页码：2492 / 2500

页数：9

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