Rhizopus microsporus in wooden tongue depressors: a major threat or minor inconvenience?

被引:21
作者
Holzel, H
Macqueen, S
MacDonald, A
Alexander, S
Campbell, CK
Johnson, EM
Warnock, DW
机构
[1] Great Ormond St Hosp Children NHS Trust, Dept Microbiol, London WC1N 3JH, England
[2] Mycol Reference Lab, Bristol, Avon, England
关键词
tongue depressors; Rhizopus microsporus; good manufacturing process;
D O I
10.1016/S0195-6701(98)90064-0
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The investigation and management of an apparent outbreak of Rhizopus spp. in a London paediatric referral centre between September 1995 and April 1996 is described. The organism was identified in microbiological surveillance samples from 23 patients nursed in four hospital areas. Investigations revealed the presence of the organism in spatulae from all ward areas investigated and from closed boxed containers held in the central hospital stores obtained from a new supplier. In contrast, culture of spatulae from the initial supplier failed to yield any fungal isolates. The incident was reported to the Medical Device Agency (MDA), the Central Public Health Laboratory Service (CPHLS) and the Birmingham PHLS. A statement was prepared for the weekly Communicable Disease Report and a hazard warning issued by the MDA. The spatulae were withdrawn from use and the contract with the original supplier was re-established. This incident resulted in contamination of samples only and no patient involvement. It highlights the problems which may follow use of equipment for unintended purposes and the need for good manufacturing practice guidelines to be applied to nonsterile equipment used in direct patient care.
引用
收藏
页码:113 / 118
页数:6
相关论文
共 16 条
[1]   A MECHANISM OF SUSCEPTIBILITY TO MUCORMYCOSIS IN DIABETIC-KETOACIDOSIS - TRANSFERRIN AND IRON AVAILABILITY [J].
ARTIS, WM ;
FOUNTAIN, JA ;
DELCHER, HK ;
JONES, HE .
DIABETES, 1982, 31 (12) :1109-1114
[2]   NOSOCOMIAL RHIZOPUS INFECTION (ZYGOMYCOSIS) IN CHILDREN [J].
DENNIS, JE ;
RHODES, KH ;
COONEY, DR ;
ROBERTS, GD .
JOURNAL OF PEDIATRICS, 1980, 96 (05) :824-828
[3]  
GALE GR, 1961, AM J MED SCI, V241, P604
[4]   HOSPITAL-ACQUIRED MUCORMYCOSIS (RHIZOPUS-RHIZOPODIFORMIS) OF SKIN AND SUBCUTANEOUS TISSUE - EPIDEMIOLOGY, MYCOLOGY AND TREATMENT [J].
GARTENBERG, G ;
BOTTONE, EJ ;
KEUSCH, GT ;
WEITZMAN, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1978, 299 (20) :1115-1118
[5]   CUTANEOUS RHIZOPUS INFECTION - OCCURRENCE AS A POST-OPERATIVE COMPLICATION ASSOCIATED WITH AN ELASTICIZED ADHESIVE DRESSING [J].
MEAD, JH ;
LUPTON, GP ;
DILLAVOU, CL ;
ODOM, RB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1979, 242 (03) :272-274
[6]   PHYCOMYCOSIS COMPLICATING LEUKEMIA AND LYMPHOMA [J].
MEYER, RD ;
ROSEN, P ;
ARMSTRONG, D .
ANNALS OF INTERNAL MEDICINE, 1972, 77 (06) :871-+
[7]   Nosocomial infection with Rhizopus microsporus in preterm infants: Association with wooden tongue depressors [J].
Mitchell, SJ ;
Gray, J ;
Morgan, MEI ;
Hocking, MD ;
Durbin, GM .
LANCET, 1996, 348 (9025) :441-443
[8]   MUCORMYCOSIS FOLLOWING BONE-MARROW TRANSPLANTATION [J].
MYSKOWSKI, PL ;
BROWN, AE ;
DINSMORE, R ;
KIEHN, T ;
EDWARDS, F ;
WONG, B ;
SAFAI, B ;
ARMSTRONG, D .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1983, 9 (01) :111-115
[9]  
OWENS WM, 1982, DIABETES, V31, P1109
[10]  
SHELDON WJ, 1959, J EXP MED, V11, P845