High-frequency stimulation of the infralimbic cortex, following behavioral suppression of PTSD-like symptoms, prevents symptom relapse in mice

被引:11
作者
Bentefour, Yassine [1 ]
Bennis, Mohamed [1 ]
Garcia, Rene [2 ,3 ]
Ba-M'hamed, Saadia [1 ]
机构
[1] Univ Cadi Ayyad, Ctr Natl Rech Sci & Tech, Lab Pharmacol Neurobiol & Comportement, URAC 37, Marrakech, Morocco
[2] Aix Marseille Univ, Inst Neurosci Timone, UMR7289, F-13385 Marseille, France
[3] CNRS, F-13385 Marseille, France
关键词
Mouse PTSD model; Relapse prevention; Brain stimulation; Prefrontal cortex; Synaptic plasticity; POSTTRAUMATIC-STRESS-DISORDER; MEDIAL PREFRONTAL CORTEX; LONG-TERM POTENTIATION; FEAR EXTINCTION MEMORY; DEEP BRAIN-STIMULATION; CONDITIONED FEAR; DOUBLE-BLIND; IN-VIVO; RATS; HIPPOCAMPAL;
D O I
10.1016/j.brs.2018.04.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: We have previously demonstrated, in mice, that antidepressant treatment can prevent relapse of PTSD-like behaviors (avoidance, hyperarousal, and anxiety) through increased activation in the infralimbic cortex (IL) of the medial prefrontal cortex. Objective: Here, we examined whether direct high-frequency stimulation (HFS) of the IL, provoking its heightened activation (i.e., long-term potentiation, LTP), would also prevent the return of PTSD-like symptoms. Methods: A 1.5-mA foot-shock was used to generate PTSD-like symptoms in Swiss mice. In Experiment 1, local field potentials were recorded in the IL to test whether normal IL LTP can be induced after the suppression of PTSD-like symptoms. In Experiment 2, IL HFS was applied after symptom suppression, but prior to the provocation of relapse, to test HFS effect on symptom return. Results: We observed that PTSD-like state was associated with impairment in IL HFS-induced IL LTP. However, IL LTP induction was near normal when PTSD-like symptoms were suppressed. We then found that IL HFS, applied after symptom suppression, prevented symptom return. Conclusions: Increased activation of the IL may be a key mechanism preventing PTSD relapse. Prefrontal cortex deep brain stimulation may, therefore, be relevant for preventing PTSD symptom return in remitted high-risk patients. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:913 / 920
页数:8
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