Ma'edamines C and D, New Bromotyrosine Alkaloids Possessing a Unique Tetrasubstituted Pyridinium Moiety from an Okinawan Marine Sponge Suberea sp.

被引：13
作者：
Kurimoto, Shin-ichiro [1 ]
Seino, Satsuki [1 ]
Fromont, Jane [2 ]
Kobayashi, Jun'ichi [3 ]
Kubota, Takaaki [1 ]
机构：
[1] Showa Pharmaceut Univ, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan
[2] Western Australian Museum, Locked Bag 49, Welshpool Dc, WA 6986, Australia
[3] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 21期
关键词：
NATURAL-PRODUCTS MAEDAMINES; CROSS-LINKAGES; TYROKERADINES;
D O I：
10.1021/acs.orglett.9b03457
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new bromotyrosine alkaloids, ma'edamines C and D, were isolated from an Okinawan marine sponge Suberea sp. The structures of ma'edamines C and D were elucidated on the basis of spectroscopic data. Ma'edamines C and D were the first natural products possessing a unique tetrasubstituted pyridinium moiety such as N-alkyl-3,5-diethyl-2-propylpyridinium and N-alkyl-3,5-diethyl-4-propylpyridinium, respectively. Ma'edamines C and D exhibited moderate cytotoxicity against murine leukemia cell line L1210 in vitro.
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收藏
页码：8824 / 8826
页数：3
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